Research articles

Water-filtered infrared A irradiation exerts antifungal effects on the skin fungus Malassezia

Magdalena de Arriba, Nicole Borel, Salomé LeibundGut-Landmann

pubmed.ncbi.nlm.nih.gov/38669741/

Epidermal barrier impairment predisposes for excessive growth of the allergy-associated yeast Malassezia on murine skin

Fiorella Ruchti, Pascale Zwicky, Burkhard Becher, Sandrine Dubrac, Salomé LeibundGut-Landmann

pubmed.ncbi.nlm.nih.gov/38385963/

γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control

Fiorella Ruchti, Meret Tuor, Liya Mathew, Neil E McCarthy, Salomé LeibundGut-Landmann

PLoS Pathog. 2024 Jan 12

pubmed.ncbi.nlm.nih.gov/38215167/

The pathogenic and colonization potential of Candida africana

Daria Kosmala, Natacha Sertour, Ricardo Fróis Martins, Luca Spaggiari, Andrea Ardizzoni, Salomé LeibundGut-Landmann, Eva Pericolini, Marie-Elisabeth Bougnoux, Christophe d'Enfert, Mélanie Legrand

Microbes Infect. 2024 Jan-Feb

pubmed.ncbi.nlm.nih.gov/37734535/

Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease

Suling Zeng, Elisa Rosati, Carina Saggau, Berith Messner, Huikuan Chu, Yi Duan, Phillipp Hartmann, Yanhan Wang, Shengyun Ma, Wendy Jia Men Huang, Jihyung Lee, Sung Min Lee, Raquel Carvalho-Gontijo, Vivian Zhang, Joseph P Hoffmann, Jay K Kolls 6, Eyal Raz, David A Brenner, Tatiana Kisseleva, Salomé LeibundGut-Landmann, Petra Bacher, Peter Stärkel, Bernd Schnabl

Cell Host Microbe. 2023 Mar 8

pubmed.ncbi.nlm.nih.gov/36893735/

The human pathobiont Malassezia furfur secreted protease Mfsap1 regulates cell dispersal and exacerbates skin inflammation

Joleen P Z Goh, Fiorella Ruchti, Si En Poh, Winston L C Koh, Kiat Yi Tan, Yan Ting Lim, Steven T G Thng, Radoslaw M Sobota, Shawn S Hoon, Chenxi Liu, Anthony J O'Donoghue, Salomé LeibundGut-Landmann, Hazel H Oon, Hao Li, Thomas L Dawson Jr

Proc Natl Acad Sci U S A. 2022 Dec 6

pubmed.ncbi.nlm.nih.gov/36442106/

Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation

Christina Lemberg , Kontxi Martinez de San Vicente, Ricardo Fróis-Martins, Simon Altmeier, Van Du T Tran, Sarah Mertens, Sara Amorim-Vaz, Laxmi Shanker Rai, Christophe d'Enfert, Marco Pagni, Dominique Sanglard, Salomé LeibundGut-Landmann

PLoS Pathog. 2022 Apr 1

pubmed.ncbi.nlm.nih.gov/35404986/

The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence

Sabrina Jenull, Theresia Mair, Michael Tscherner, Philipp Penninger, Florian Zwolanek, Fitz-Gerald S Silao, Kontxi Martinez de San Vicente, Michael Riedelberger, Naga C Bandari, Raju Shivarathri, Andriy Petryshyn, Neeraj Chauhan, Lucia F Zacchi, Salomé LeibundGut-Landmann, Per O Ljungdahl, Karl Kuchler

Cell Rep. 2021 Jul 20

pubmed.ncbi.nlm.nih.gov/34289370/

IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation

Pascale Zwicky, Florian Ingelfinger, Bruno Marcel Silva de Melo, Fiorella Ruchti, Stefanie Schärli, Nicole Puertas, Mirjam Lutz, Truong San Phan, Thomas M Kündig, Mitchell P Levesque, Julia-Tatjana Maul, Christoph Schlapbach, Salomé LeibundGut-Landmann, Sarah Mundt, Burkhard Becher

Sci Immunol. 2021 Oct 22

pubmed.ncbi.nlm.nih.gov/34678045/

Mutanobactin D from the Human Microbiome: Total Synthesis, Configurational Assignment, and Biological Evaluation

Felix Pultar, Moritz E Hansen, Susanne Wolfrum, Lennard Böselt, Ricardo Fróis-Martins, Susanne Bloch, Alberto G Kravina, Deren Pehlivanoglu, Christina Schäffer, Salomé LeibundGut-Landmann, Sereina Riniker, Erick M Carreira

J Am Chem Soc. 2021 Jul 2. doi: 10.1021

pubmed.ncbi.nlm.nih.gov/34212720/

Tissue-Resident Memory T Cells in Antifungal Immunity

Salomé LeibundGut-Landmann

Front Immunol. 2021 May 25;12:693055

pubmed.ncbi.nlm.nih.gov/34113356

CD85k Contributes to Regulatory T Cell Function in Chronic Viral Infections

Anna Estrada Brull, Felix Rost, Josua Oderbolz, Florian R Kirchner, Salomé Leibundgut-Landmann, Annette Oxenius, Nicole Joller
Int J Mol Sci. 2020 Dec 22

pubmed.ncbi.nlm.nih.gov/33375121/

Agranulocytosis leads to intestinal Echinococcus multilocularis oncosphere invasion and hepatic metacestode development in naturally resistant Wistar rats

D. E. Joekel , S. Nur , J. Monné Rodriguez , P. A. Kronenberg , A. Kipar, S. LeibundGut-Landmann, P. Deplazes
Parasitology 2020 Oct 22;1-33

pubmed.ncbi.nlm.nih.gov/33087186/

A Novel Mycovirus Evokes Transcriptional Rewiring in the Fungus Malassezia and Stimulates Beta Interferon Production in Macrophages

S. Applen Clancey, F. Ruchti, S. LeibundGut-Landmann, J. Heitman, G. Ianiri
mBio. 2020 Sep 1

pubmed.ncbi.nlm.nih.gov/32873760/

Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa

F.R. Kirchner, S. LeibundGut-Landmann
Mucosal Immunol. 2020 Jul 27

pubmed.ncbi.nlm.nih.gov/32719409/

HGT in the human and skin commensal Malassezia: A bacterially derived flavohemoglobin is required for NO resistance and host interaction

G. Ianiri, M. A. Coelho, F.Ruchti, F. Sparber, T. J. McMahon, Ci Fu, M. Bolejack, O. Donovan, H. Simutney, P. Myler, F. Dietrich, D. Fox 3rd, S. LeibundGut-Landmann, J Heitman
Proc Natl Acad Sci U S A 2020 Jul 7

pubmed.ncbi.nlm.nih.gov/32576698/

IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival

S. Nur, F. Sparber, C. Lemberg, E. Guiducci, T. A. Schweizer, P. Zwicky, B. Becher, S. LeibundGut-Landmann
PLoS Pathog 2019 Dec

pubmed.ncbi.nlm.nih.gov/31887131/

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

F.Sparber, S. LeibundGut-Landmann
J Vis Exp 2019 Nov 6

pubmed.ncbi.nlm.nih.gov/31762452/

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, LeibundGut-Landmann S., et al.
Eur J Immunol. 2019 Oct

pubmed.ncbi.nlm.nih.gov/31633216/

Role of NS1 and TLR3 in Pathogenesis and Immunity of WNV

Patel S, Sinigaglia A, Barzon L, Fassan M, Sparber F, LeibundGut-Landmann S, Ackermann M.
Viruses 2019 Jul 3

pubmed.ncbi.nlm.nih.gov/31277274/

Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression.

Kirchner FR, Littringer K, Altmeier S, Tran VDT, Schönherr F, Lemberg C, Pagni M, Sanglard D, Joller N, LeibundGut-Landmann S.
Front. Immunol. 2019 February 27

pubmed.ncbi.nlm.nih.gov/30873177/

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation.

Sparber F, De Gregorio C, Steckholzer S, Ferreira FM, Dolowschiak T, Ruchti F, Kirchner FR, Mertens S, Prinz I, Joller N, Buch T, Glatz M, Sallusto F, LeibundGut-Landmann S.
Cell Host Microbe. 2019 Mar 13

pubmed.ncbi.nlm.nih.gov/30870621/

Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide.

Wendler J, Schroeder BO, Ehmann, D. Koeninger, L. Mailänder-Sánchez D, Lemberg C, Wanner S, Schaller M, Stange EF, Malek NP, Weidenmaier C, LeibundGut-Landmann S, Wehkamp J.

Sci Rep. 2019 Mar 6

pubmed.ncbi.nlm.nih.gov/30842543/

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.

Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, Minnerup L, Saz-Leal P, Slack E, Kemp B, Gisbert JP, Dzionek A, Robinson MJ, Rupérez FJ, Cerf-Bensussan N, Brown GD, Bernardo D, LeibundGut-Landmann S, Sancho D.
Immunity. 2019 Jan 21

pubmed.ncbi.nlm.nih.gov/30709742/

Correction: Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection

Whitney PG, Bär E, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S, Reis e Sousa C.
PLoS Pathog. 2018 Nov 21

pubmed.ncbi.nlm.nih.gov/30462735/

The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size.

Fuchs K, Cardona Gloria Y, Wolz OO, Herster F, Sharma L, Dillen CA, Täumer C, Dickhöfer S, Bittner Z, Dang TM, Singh A, Haischer D, Schlöffel MA, Koymans KJ, Sanmuganantham T, Krach M, Roger T, Le Roy D, Schilling NA, Frauhammer F, Miller LS, Nürnberger T, LeibundGut-Landmann S, Gust AA, Macek B, Frank M, Gouttefangeas C, Dela Cruz CS, Hartl D, Weber AN.
EMBO Rep. 2018 Dec 19

pubmed.ncbi.nlm.nih.gov/30337494/

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4

Guiducci E, Lemberg C, Küng N, Schraner E, Theocharides APA, LeibundGut-Landmann S.
Front Immunol. 2018 Jul 9

pubmed.ncbi.nlm.nih.gov/30038623/

Common Features of Regulatory T Cell Specialization During Th1 Responses.

Littringer K, Moresi C, Rakebrandt N, Zhou X, Schorer M, Dolowschiak T, Kirchner F, Rost F, Keller CW, McHugh D, LeibundGut-Landmann S, Robinson MD, Joller N.
Front. Immunol. 2018 June 13

pubmed.ncbi.nlm.nih.gov/29951069/

Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.

Sparber F, Dolowschiak T, Mertens S, Lauener L, Clausen BE, Joller N, Stoitzner P, Tussiwand R, LeibundGut-Landmann S,
PLoS Pathog. 2018 May 21

pubmed.ncbi.nlm.nih.gov/29782555/

Identification of Candida albicans regulatory genes governing mucosal infection.

Meir J, Hartmann E, Eckstein MT, Guiducci E, Kirchner F, Rosenwald A, LeibundGut-Landmann S, Pérez JC.
Cell Microbiol. 2018 Aug 20

pubmed.ncbi.nlm.nih.gov/29575428/

Guidelines for the use of flow cytometry and cell sorting in immunological studies

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S,et al.
Eur J Immunol. 2017 Oct

pubmed.ncbi.nlm.nih.gov/29023707/

The two-component response regulator Skn7 belongs to a network of transcription factors regulating morphogenesis in Candida albicans and independently limits morphogenesis-induced ROS accumulation.

Basso V, Znaidi S, Lagage V, Cabral V, Schoenherr F, LeibundGut-Landmann S, d'Enfert C, Bachellier-Bassi S.
Mol Microbiol. 2017 Oct 10

pubmed.ncbi.nlm.nih.gov/28752552/

The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity.

Schönherr FA, Sparber F, Kirchner FR, Guiducci E, Trautwein-Weidner K, Gladiator A, Sertour N, Hetzel U, Le GTT, Pavelka N, d'Enfert C, Bougnoux ME, Corti CF, LeibundGut-Landmann S.
Mucosal Immunol. 2017 Sep 10

pubmed.ncbi.nlm.nih.gov/28176789/

Assessment of Immune Responses to Fungal Infections: Identification and Characterization of Immune Cells in the Infected Tissue

Sparber F, LeibundGut-Landmann S.
Methods Mol Biol. 2017

pubmed.ncbi.nlm.nih.gov/27837503/

IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa

Altmeier S, Toska A, Sparber F, Teijeira A, Halin C, LeibundGut-Landmann S.
PLoS Pathog. 2016 Sep 15

pubmed.ncbi.nlm.nih.gov/27632536/

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An NK cell perforin response elicited via IL-18 controls mucosal inflammation kinetics during Salmonella gut infection.

Müller AA, Dolowschiak T, Sellin ME, Felmy B, Verbree C, Gadietn S, Westermann A, Vogel J, LeibundGut-Landmann S, Hardt WD.
2016 PLoS Pathogens. 12(6): e1005723

Immune recovery in HIV-infected patients after Candida esophagitis is impaired despite long-term antiretroviral therapy.

Stuehler C, Bernardini C, Elzi L, Stockle M, Zimmerli S, Furrer H, Günthard HF, LeibundGut-Ladmann S, Battegay M, Khanna N and the Swiss HIV Cohort Study.
2016 AIDS. 30(12):1923-33

Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis.

Trautwein-Weidner K*, Gladiator A*, Kirchner FR, Becattini S, Rülicke T, Sallusto F and Leibundgut-Landmann S.
2015 PLoS Pathog 11(10): e1005164 [[* equal contribution]

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

Whitney PG*, Bär E*, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S†, Reis E Sousa C†.
2014 PLoS Pathog. 10(7):e1004276. [*,†: equal contribution ]

IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils.

Trautwein-Weidner K*, Gladiator A*, Nur S, Diethelm P, Leibundgut-Landmann S. [* equal contribution]
2015 Mucosal Immunology, 8: 221

Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance.

Dubrot J, Duraes FV, Potin L, Capotosti F, Brighouse D, Suter T, LeibundGut-Landmann S, Garbi N, Reith W, Swartz MA, Hugues S.
2014 J Exp Med. 211(6):1153-66

IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells.

Bär E, Whitney PG, Moor K, Reis E Sousa C, Leibundgut-Landmann S,
Immunity. 2014 40 (1): 117-27

Gain of function mutations in CgPDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells.

Vale-Silva L, Ischer F, LeibundGut-Landmann S and Sanglard D.
2013 Infect Immun., 81: 1709.

Rapid and serial quantification of adhesion forces of yeast and Mammalian cells

Potthoff E, Guillaume-Gentil O, Ossola D, Polesel-Maris J, LeibundGut-Landmann S, Zambelli T, Vorholt JA.
PLoS One 2012;7(12):e52712

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells are Essential for Host Defense against Fungal Infection.

Gladiator A, Wangler N, Trautwein-Weidner K, LeibundGut-Landmann S.
2013 J. Immunol. 190(2): 521-5

Glycoengineering of host mimicking type-2 LacNAc polymers and Lewis X antigens on bacterial cell surfaces.

Mally M, Fontana C, LeibundGut-Landmann S, Laacisse L, Fan YY, Widmalm G and Aebi M.
2013 Mol. Micro., 87: 112

A novel Th cell epitope of Candida albicans mediates protection from fungal infection.

Bär E, Gladiator A, Bastidas S, Roschitzki B, Acha-Orbea H, Oxenius A, LeibundGut-Landmann S.
2012 J. Immunol. 188: 5636

Inflammasome activation and IL-1b target IL-1a for secretion as opposed to surface expression.

Fettelschoss A, Kistowska M, LeibundGut-Landmann S, Beer HD, Johansen P, Senti G, Contassot E, Bachmann MF, French LE, Oxenius A, Kündig TM.
2011 PNAS, 2011 108:18055

Nonhematopoietic cells are key players in innate control of bacterial airway infection.

LeibundGut-Landmann S, Weidner K, Hilbi H and Oxenius A.
2011 J.Immunol. 186: 3130

DC activated via Dectin-1 convert regulatory T cells into Th17 producers.

Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G and Reis e Sousa C.
2008 Eur.J.Immunol. 38: 3274

Stimulation of dendritic cells via the Dectin-1 / Syk pathway allows priming of cytotoxic T cell responses.

LeibundGut-Landmann S, Osorio F, Brown GD and Reis e Sousa C.
2008 Blood. 112: 4971

Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo.

Worsley AGF #, LeibundGut-Landmann S #, Slack EC, Phng LK, Gerhardt H, Reis e Sousa C and MacDonald AS. 2008 Eur.J.Immunol. 38: 1043 [# equal contribution]

Dendritic cell quiescence under systemic inflammation driven by radioresistant cells in vivo.

Nolte M, LeibundGut-Landmann S, Joffre O and Reis e Sousa C.
2007 J.Exp.Med., 204: 1487

Syk- and Card9-dependent coupling of innate immunity to induction of T helper cells that produce interleukin 17.

LeibundGut-Landmann S, Groß O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J and Reis e Sousa C.
2007 Nat Immunol., 8: 630

Circulating, soluble forms of major histocompatility complex antigens are not exosome-associated.

MacKay P, LeibundGut-Landmann S, Koch N, Reith W, Jack RW, McLellan A.
2006 Eur.J.Immunol., 35: 2875

Revisiting the specificity of the MHC class II transactivator CIITA in vivo

Otten L, Lavanchy C, Barras E, LeibundGut-Landmann S, Kos-Braun I, Huarte J, Steimle V, Acha-Orbea H, Reith W. 2006 Eur.J.Immunol., 35: 1548

MHC class II expression is regulated differentially between plasmacytoid and conventional dendritic cells.

LeibundGut-Landmann S, Waldburger JM, Reis e Sousa C, Acha-Orbea H, Reith W.
2004 Nat.Immunol., 5: 899-908

Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression.

Landmann S, Mühlethaler-Mottet A, Bernasconi L, Suter T, Waldburger JM, Masternak K, Arrighi JF, Hauser C, Fontana A, Reith W.
2001 J.Exp.Med., 194: 379-391

Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue.

Ludewig B, Odermatt B, Landmann S, Hengartner H, Zinkernagel RM.
1998 J.Exp.Med., 188: 1493-1501